Naomi Osaka sure seems like herself again.

The former world No. 1 is through to the third round at the Miami Open, easily handling 13th-seeded Angelique Kerber of Germany 6-2, 6-3 on Thursday. It was every bit as one-sided?as the score made it seem, with Osaka winning 89% of first-serve points and 61 of the 100 points played in the match?overall.

“It means a lot to me,” said Osaka, unseeded in Miami after?falling to No. 77 in the world because she's missed?considerable time to focus on her mental health in recent?years. “She's the first high-seeded player I've beaten this?year.”?

Osaka's win set the tone for a day where 11 seeded women were ousted from the tournament, a stunning series of results?headlined by Romania's Irina-Camelia Begu defeating top-seeded Aryna Sabalenka 6-4, 6-4. Begu had lost 17 of her last?18 matches against top-10 players entering Thursday.

Also gone: No. 3 seed Anett Kontaveit. She lost to Ann Li, a?21-year-old American who got her first win over a top-10?opponent — a 6-0, 3-6, 6-4 triumph.

Kerber is ranked 15th in the world; the last time Osaka?defeated a top-15 ranked player was when she topped then-No. 10 Serena Williams in the 2021 Australian Open semifinals. Osaka went on to win that tournament and hasn't been to a final since, but her win over Kerber — who had been?4-1 against Osaka entering Thursday — certainly made her?look the part of a Miami contender.

“I went into the match just really wanting to play my game,” said Osaka, who has yet to drop a set in her two matches in?Miami; she beat Astra Sharma 6-3, 6-4 on Wednesday.?

“I still have the memories of all the matches she's beaten me?before. So yeah, I just wanted to play as well as I could. It?worked out.”?

The rest of the ousted women's seeds: No. 6 Karolina?Pliskova, No. 11 Emma Raducanu, No. 15 Elina Svitolina, No. 18 Leylah Fernandez, No. 19 Tamara Zidansek, No. 25 Daria?Kasatkina, No. 31 Alize Cornet and No. 32 Sara Sorribes Tormo, all of them defeated Thursday.

Pliskova — in just her second match after missing about four?months with a broken arm — lost 6-3, 6-3 to qualifier Anna?Kalinskaya.?

Olympic doubles gold medalist Katarina Siniakova of the?Czech Republic needed just under three hours to beat?Raducanu, the reigning U.S. Open champion, 3-6, 6-4, 7-5.?Siniakova was nearly reduced to tears while getting worked on?during a medical time-out in the first set because of an?upper-body injury.

“I think I just felt better as the match was going on,"?Siniakova said. “I was fighting in the beginning."?

Svitolina, who had a number of fans wearing pro-Ukraine shirts watching her match in tribute to her homeland, lost to?Britain's Heather Watson 4-6, 6-3, 7-6 (4).

“I really feel for Elina," Watson said. “I can see she's not her?normal self. ... She must just have so much on her mind. I?think it's amazing that she's out here still competing."?

Fernandez — a U.S. Open finalist last year — lost to Karolina?Muchova of the Czech Republic 6-4, 7-6 (3).

Muchova, who hasn't played since the U.S. Open nearly seven?months ago because of an abdominal injury, will face Osaka?for a spot in the round of 16.

“For me, it was a win to play and compete again,” Muchova?said.

Vera Zvonareva topped Zidansek, 6-3, 6-2. Cornet lost to?Alison Riske of the U.S. 6-2, 6-2. Kasatkina fell to Aliaksandra?Sasnovich of Belarus 7-6 (5), 6-4, and Sorribes Tormo was?ousted by Kaia Kanepi of Estonia 3-6, 7-5, 6-0.

No. 9 seed Danielle Collins of the U.S. escaped the upset bug,?holding off Anna Bondar of Hungary 6-3, 3-6, 6-4. No. 8 seed?Ons Jabeur was another winner, getting past Poland's Magda?Linette 7-6 (1), 6-2, and No. 22 Belinda Bencic eased by Maria Kostyuk 6-3, 6-1.

Among the men's winners was two-time Miami Open winner?Andy Murray, a 7-6 (4), 6-1) winner over Federico Delbonis to?earn a second-round matchup against No. 1 seed Daniil?Medvedev. Murray won the event in 2009 and 2013 when it?was held at its former Key Biscayne home.

“Obviously, a tough match," Murray said of the looming?matchup with Medvedev.?

“He's played extremely well on hard courts the last few?seasons. He appears to be right up there at the top of the?game. It'll be a big challenge, a great test."?

Sebastian Korda of the U.S., who made the quarterfinals at?Miami last year, rolled past Alejandro Davidovich Fokina of?Spain 6-1, 6-1 in a first-round match. He got off the court in?just over an hour on a summer-like day in South Florida.

“I'm a Florida boy,” Korda said. “I love the humidity. Heat and?humidity, those are my two favorite things. I just play some?really good tennis in them.”